RTG 2737 – STRESSistance

Publications

2026

  • Ebding J, Barth M, Lion LM, Gackstatter A, Link S, Pirritano M, Gasparoni G, Simon M, Herrmann J, Pielage J (2026). Mitochondrial protein import stress causes progressive neurodegeneration opposed by PERK – eIF2α signalling. biorxiv. doi: 10.64898/2026.04.10.717732 (This article is a preprint and has not been certified by peer review)

 

  • Mushtaq Z, Lasser DA, Lion LM, Ebding J, Escribano B, Burkhalter D, Moreno E, Maritzen T, Stephan R, Pielage J (2026). Loss of NudE-mediated dynein activation at synaptic terminals causes progressive axon length-dependent neurodegeneration. biorxiv. doi: 10.64898/2026.04.12.717987 (This article is a preprint and has not been certified by peer review)

 

  • Probst A, Schmollinger S, Berg J, Unger A, Strenkert D, Geimer S, Sommer F, Schroda M (2026) Depletion of chloroplast HSP70B triggers proteostasis collapse and compromises thylakoid membrane integrity in Chlamydomonas. biorxiv. doi: 10.64898/2026.04.02.716084 (This article is a preprint and has not been certified by peer review)

 

  • Arystanbek Kyzy M, Jung F, Mühlhaus T, Müller V, Reinhardt F, Heide A, Bellin L, Keller I, Neuhaus HE (2026) Early-Response to Dehydration 6-Like 14 is a vacuolar sugar importer required for acclimation to fluctuating light. Plant Physiol, in press

 

  • Mazzone FR, Graessle G, Storchova Z, Raeschle M, Maritzen T (2026) Analysis of stress-induced surfaceome remodeling reveals surface accumulation of the cation-independent mannose-6-phosphate receptor (CI-M6PR). bioRxiv. doi: 10.64898/2026.02.26.708128 (This article is a preprint and has not been certified by peer review)

 

  • Zimmermann J, Lang L, Malo Pueyo J, Riedel M, Wahni K, Stobbe D, Leiskau L, Aref E, Lux C, Janvier S, Vertommen D, Lenhard S, Hannemann F, Thangamuragan S, Castro H, Helms V, Tomas AM, Herrmann JM, Salvador A, Mühlhaus T, Riemer J, Messens J*, Deponte M*, Morgan B* (2026) Heterooligomerization drives structural plasticity of eukaryotic peroxiredoxins. Nature Chem Biol (2026). doi: 10.1038/s41589-026-02157-6

 

  • Hoffmann Y, Egeler A, Rödl S, Herrmann JM (2026) The IQ-compete assay for measuring mitochondrial protein import efficiencies in living yeast cells. FEBS Lett 600, 48-62. doi: 10.1002/1873-3468.70206

 

  • Kizmaz B, Nutz A, Hess S, Hagen J, Guerrero-Castillo S, Cabrera-Orefice A, Yoo CM, Osman C, Räschle M, Rhee HW, Herrmann JM (2026) The mitochondrial cohibitin complex facilitates the biogenesis of inner membrane proteins. bioRxiv 2026.01.12.699002. doi: 10.64898/2026.01.12.699002 (This article is a preprint and has not been certified by peer review)

 

 

2025

  • König K, Misir M, Niemeyer J, Gabelmann S, Zeilfelder S, Sommer F, Schroda M (2025). The proxiomes of CDJ5 and PGRL1 in Chlamydomonas reinhardtii overlap depending on the ability of CDJ5 to bind a 4Fe-4S cluster. bioRxiv: 2025.2008.2022.671721. doi: 10.1101/2025.08.22.671721 (This article is a preprint and has not been certified by peer review)

 

  • Lang L*, Leiskau L*, Bambach L, Deponte M (2025) H2S is a potential universal reducing agent for Prx6-type peroxiredoxins. Advanced Science 12: e07214. doi: 10.1002/advs.202507214 (shared first authorship)

 

  • Rödl S, Hoffman Y, Jung F, Egeler A, Nutz A, Räschle M, Storchová S, Mühlhaus T, Herrmann JM (2025) A protein-specific priority code in presequences determines the efficiency of mitochondrial protein import. PLoS Biol 23, e3003298. doi: 10.1371/journal.pbio.3003298

 

  • Lang J, König K, Venn B, Zeilfelder S, Ostermeier M, Spaniol B, Spaniol L, Sommer F, Mustas M, Geimer S, Furtges T, Brzezowski P, Zabret J, Wollman FA, Nowacyzk MM, Scheuring D, Rudack T, Mühlhaus T, Choquet Y, Schroda M (2025) Complexome profiling of the Chlamydomonas psb28 mutant reveals TEF5 as an early photosystem II assembly factor. Plant Cell 37, koaf055. doi: 10.1093/plcell/koaf055

 

  • Berg J, Martins Rodrigues C, Scheid C, Pirrotte Y, Picco C, Scholz-Starke J, Zierer W, Czarnecki O, Hackenberg D, Ludewig Frank, Koch W, Neuhaus E, Müdsam C, Pommerrenig B, Keller Isabel (2025) The vacuolar inositol transporter BvINT1;1 contributes to raffinose biosynthesis and reactive oxygen species scavenging during cold stress in sugar beet. Plant Cell Environ 48, 3471-3486. doi: 10.1111/pce.15367

 

  • Probst A, Knochenhauer D, Niemeyer J, Fischer L, Schroda M (2025) Internalization of affinity tags enables the purification of secreted Chlamydomonas proteins. Curr Genet 71. doi: 10.1007/s00294-025-01311-2

 

  • Amponsah PS, Bökenkamp JE, Kurpa O, Lenhard S, Myronova A, Vega Velazquez DO, Hirschelmann C, Behrends C, Herrmann JM, Räschle M, Storchová Z (2025) Aneuploidy-induced proteostasis disruption impairs mitochondrial functions and mediates aggregation of mitochondrial precursor proteins through SQSTM1/p62. Nat Commun 16, 5328. doi: 10.1038/s41467-025-60857-4

 

  • Ebding J, Mazzone F, Kins S, Pielage J, Maritzen T (2025) How neurons cope with oxidative stress. Biol Chem 2025 Feb 25. doi: 10.1515/hsz-2024-0146. Epub ahead of print. PMID: 39988910. doi: 10.1515/hsz-2024-0146

 

 

  • Jung F, Zimmer D, Mühlhaus T (2025) Computational strategies in systems-level stress response data analysis. Biological Chemistry, vol. 406, 159-172. doi: 10.1515/hsz-2025-0109

 

  • Bökenkamp JE, Keuper K, Redel S, Barthel K, Johnson L, Becker A, Wieland A, Räschle M, Storchová Z (2025) Proteogenomic analysis reveals adaptive strategies for alleviating the consequences of aneuploidy in cancer. EMBO J 44, 1829-1865. doi: 10.1038/s44318-025-00372-w

 

2024

  • Tamanna SS, Boden JS, Kaiser KM, Wannicke N, Hoering J, Sanchez-Baracaldo P, Deponte M, Frankenberg-Dinkel N, Gehringer MM (2024) Early-branching cyanobacteria up-regulate superoxide dismutase activity under a simulated early Earth anoxic atmosphere. Geobiology 22, e70005. doi: 10.1111/gbi.70005

  • Jung F, Rödl S, Herrmann JM, Mühlhaus T (2024) Analysis and prediction of internal mitochondrial targeting signals. Methods Enzymol 706, 263-283. doi: 10.1016/bs.mie.2024.07.038

  • Cheng J*, Arystanbek Kyzy M*, Heide A, Khan A, Lehmann M, Schröder L, Nägele T, Pommerrenig B, Keller I, Neuhaus HE (2024) Senescence-Associated Sugar Transporter1 affects developmental master regulators and controls senescence in Arabidopsis. Plant Physiol 196, 2749-2767. doi: 10.1093/plphys/kiae430 (*Equal contribution)

  • Kizmaz B, Nutz A, Egeler A, Herrmann JM (2024) Protein insertion into the inner membrane of mitochondria: routes and mechanisms. FEBS Open Bio 14, 1627-1639. doi: 10.1002/2211-5463.13806

  • Bertgen L, Bökenkamp JE, Schneckmann T, Koch C, Räschle M, Storchová Z, Herrmann JM (2024) Distinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress. Cell Rep 43, 1-23. doi: 10.1016/j.celrep.2024.114018

  • Hieronimus K, Donauer T, Klein J, Hinkel B, Spänle JV, Probst A, Niemeyer J, Kibrom S, Kiefer AM, Schneider L, Husemann B, Bischoff E, Möhring S, Bayer N, Klein D, Engels A, Ziehmer BG, Stieß J, Moroka P, Schroda M, Deponte M (2024) A modular cloning toolkit for the production of recombinant proteins in Leishmania tarentolae. Microbial Cell 11, 128-42. doi: 10.15698/mic2024.04.821

  • Zeilfelder S, Schroda M (2024) Das ESCRT-III-Homolog VIPP1 vermittelt Thylakoid-Biogenese und -Erhaltung. Biospektrum 30, 147–149. doi: 10.1007/s12268-024-2143-8

  • Geissel F*, Lang L*, Husemann B, Morgan B, Deponte M (2024) Deciphering the mechanism of glutaredoxin-catalyzed roGFP2 redox sensing reveals a ternary complex with glutathione for protein disulfide reduction. Nat Commun 15, 1733. doi: 10.1038/s41467-024-45808-9

 

  • Bohle F, Rossi J, Tamanna S, Jansohn H, Schlosser M, Reinhardt F, Brox A, Bethmann S, Kopriva S, Trentmann O, Jahns P, Deponte M, Schwarzlander M, Trost P, Zaffagnini M, Meyer AJ, Müller-Schüssele SJ (2024) Chloroplasts lacking class I glutaredoxins are functional but show a delayed recovery of protein cysteinyl redox state after oxidative challenge. Redox Biol 69, 103015. doi: 10.1016/j.redox.2023.103015

2023

  • Lenhard S, Gerlich S, Khan A, Rödl S, Bökenkamp JE, Peker E, Zarges C, Faust J, Storchová Z, Räschle M, Riemer J, Herrmann JM (2023) The Orf9b protein of SARS-CoV-2 modulates mitochondrial protein biogenesis. J Cell Biol 222, e202303002. doi: 10.1083/jcb.202303002

 

  • Vollweiter D, Shergill JK, Hilse A, Kochlamazashvili G, Koch SP, Mueller S, Boehm-Sturm P, Haucke V, Maritzen T (2023) Intersectin deficiency impairs cortico-striatal neurotransmission and causes obsessive-compulsive behaviors in mice. Proc Natl Acad Sci USA 120, e2304323120. doi: 10.1073/pnas.2304323120

 

  • Bischoff E, Lang L, Zimmermann J, Luczak M, Kiefer AM, Niedner-Schatteburg G, Manolikakes G, Morgan B, Deponte M (2024) Glutathione kinetically outcompetes reactions between dimedone and a cyclic sulfenamide or physiological sulfenic acids. Free Radic Biol Med 208, 165-77. doi: 10.1016/j.freeradbiomed.2023.08.005

 

  • Siitonen V, Probst A, Tóth G, Kourist R, Schroda M, Kosourov S, Allahverdiyeva Y (2023) Engineered green alga Chlamydomonas reinhardtii as a whole-cell photosynthetic biocatalyst for stepwise photoproduction of H2 and ε-caprolactone. Green Chemistry 25, 5945-5955. doi: 10.1039/D3GC01400B

 

 

  • Rödl S, Herrmann JM (2023) The role of the proteasome in mitochondrial protein quality control. IUBMB Life 75, 868-879. doi: 10.1002/iub.2734

 

  • Jung F, Frey K, Zimmer D, Mühlhaus T (2023) DeepSTABp: a deep learning approach for the prediction of thermal protein stability. Int J of Mol Sci 24, 7444. doi: 10.3390/ijms24087444

 

 

2022

  • Güngör B, Flohr T, Garg SG, Herrmann JM (2022) The ER membrane complex (EMC) can functionally replace the Oxa1 insertase in mitochondria. PLoS Biol 20, e3001380. doi: 10.1371/journal.pbio.3001380

 

  • Rödl S, den Brave F, Räschle M, Kizmaz B, Lenhard S, Groh C, Becker H, Zimmermann J, Morgan B, Richling E, Becker T, Herrmann JM (2023) The metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import. Life Science Alliance 6, e202201526. doi: 10.26508/lsa.202201526

 

  • Mushtaq Z, Aavula K, Lasser DA, Kieweg ID, Lion LM, Kins S, Pielage J (2022) Madm/NRBP1 mediates synaptic maintenance and neurodegeneration-induced presynaptic homeostatic potentiation. Cell Reports 41, 111710. doi: 10.1016/j.celrep.2022.111710

 

  • Kiefer AM, Niemeyer J, Probst A, Erkel G, Schroda M (2022) Production and secretion of functional SARS-CoV-2 spike protein in Chlamydomonas reinhardtii. Front Plant Sci 13, 988870. doi: 10.3389/fpls.2022.988870

 

  • Bernhard SV, Seget-Trzensiok K, Kuffer C, Krastev DB, Stautmeister LM, Theis M, Keuper K, Boekenkamp JE, Kschischo M, Buchholz F, Storchová Z (2022) Loss of USP28 and SPINT2 expression promotes cancer cell survival after whole genome doubling. Cell Oncol (Dordr) 45, 103-119. doi: 10.1007/s13402-021-00654-5