From October 4-6, 2022, our first symposium took place in Freinsheim. We would like to sincerely thank all participants, our PIs and especially our PhD students and external guest scientists Jun.-Prof. Bianca Schrul and Prof. em. Richard Zimmermann (both Medical Biochemistry & Molecular Biology, Saarland University) as well as Prof. Bruce Morgan (Biochemistry, Saarland University) for the many exciting lectures and the extensive further discussions. All together it resulted in a really successful event.